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Modelling pharmaceutical capsule filling processes

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  Job/Thema Modelling pharmaceutical capsule filling processes  
 
  Beschreibung The Research Center Pharmaceutical Engineering GmbH (RCPE) is a Research Center in the field of Pharmaceutical Engineering. Our goal is to establish technology to transform current product and processes development approaches in the pharmaceutical and diagnostics industries into a science-based endeavor together with our partners.


PAID DIPLOMA THESIS
Modelling pharmaceutical capsule filling processes
Ref.Nr. DA19

We offer students studying Process Engineering, Mechanical Engineering, Physics, Mathematics, Biomedical Engineering, or similar disciplines the chance to work on their master thesis within the scope of the following research project.

SCOPE OF THE PROJECT: Capsules are one of the main types of pharmaceutical products. Capsule filling process involves several process parameters (i.e. size of nozzles, speed of operation, piston displacement, etc) and is affected by several powder properties (i.e. flowability, cohesion, compressibility, particle size, mechanical properties of the particles, etc).
These parameters affect the weight variability among capsules, which poses a challenge to pharmaceutical manufacturers because capsules must comply with strict regulations (i.e. USP and EP). This project is about using the tools available in commercial software (EDEM) to simulate the behavior of a collection of particles in a capsule filling scenario. You will develop models that will help understand the effect of selected process and powder variables. You will work in close collaboration with experimentalists to validate the simulations.

YOUR DUTIES AND RESPONSIBILITIES:
- Learn how to use EDEM software.
- Model and perform simulations for the different relevant phases in capsule filling: nozzle lowering, compaction, load relieving, nozzle lifting, powder plug ejection.
- Analyzing results
- Compare with literature and experimental data

START: may start work immediately

Ideal candidates will already have experience in the field of CAD/Matlab or computer simulation.

WE OFFER:
- a multidisciplinary and dynamic research environment in the area of pharmaceutical technology,
- Mentoring and on-the-job training by a our qualified staff, and
- an adequate payment as well as the chance for personal and technical development in the area of pharmaceutical engineering.

We look forward to receiving your application!

Research Center Pharmaceutical Engineering GmbH
Mag. Simone Gritzner
Inffeldgasse 21A/II, A-8010 Graz
Tel.: +43 316 873-9704
simone.gritzner@rcpe.at
 
 
  gesuchte Partner aus dem Bereich fhuni, sonstiges  
 
  gewünschte Job/Projektart Masterthesis  
 
  Branche Industrie, Gesundheit, Sonstiges  
 
  Berufsfeld Technik/Produktion/IT, Sonstiges  
 
  Vergütung nach Vereinbarung  
 
  Ansprechpartner Research Center Pharmaceutical Engineering GmbH
Mag. Simone Klein
Inffeldgasse 13
8010 Graz
http://www.rcpe.at